BIOL3190 Lecture Notes - Lecture 5: Balancing Selection, Haplotype, Valine
Document Summary
Announcement: exam one week from today, canvas will have a place to ask questions. Founder mutations can be distinguished by the haplotype where they reside. Selection can increase the frequency of a mutation that provides favorable phenotype. Four different inheritance patterns depend on the chromosome carrying the mutation: autosomes- one from each parent, y- father to son, x- pattern differs in males and females, mitochondrial dna- matrilineal. As humans populated the earths continents, mutations generated new snp"s. Mutations in the non-recombining regions of the y chromosome can be used to track migration back to common ancestor 275,000 years ago. Mitochondrial dna passed between generations by mom: mitochondrial have a very small circular genome that doesn"t recombine, all mitochondrial haplotypes share a common ancestor dated 150,000-200,000 years ago in africa. Founder mutations found at high frequencies in groups that are geographically or culturally isolated.
