BIOL 3210 Lecture Notes - Lecture 14: Cell Nucleus, Electronegativity, Competitive Inhibition
Document Summary
Catalytic role: metalloenymes contain tightly bound metal ion cofactors: iron, copper, zinc, increase the acidity to generate a nucleophile. When co2 is dissolved in water, there is acidification of the water (think of the oceans and the ph getting smaller! ) oceans don"t have enzymes: co2 is a waste product we want bicarbonate to form it"s a buffer for our blood! Helps us move the co2 through our system: zinc lowers the pka of water to 7. Water gives up a proton and becomes a negative hydroxyl (neutral ph) The hydroxide can attack the electropositive carbon of co@ to generate carbonic acid: the zinc initiates proton shuttle leaves the water and binds nearby histidine. Proton donated to a base in solution. Water histidine base in solution: can be used to treat glaucoma. Bicarbonate is produced by ciliary body in eye and leads to more water in a certain chamber to the eye (osmosis) increase in the intraocular pressure.
