BIOL 4510 Lecture Notes - Lecture 12: Ectodomain, Intrinsically Disordered Proteins, Fusion Gene
10 Mar 2018
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Exam: 7 signaling pathways, 3 of them are ras. Other mammalian receptor classes (know general pathway: hematopoietic receptor class, receptors control development of blood cells epo tpo receptors. February 12: 2 kinases linked to intracellular tail. In an activated state when bound to gtp. Lecture 12: most important receptors in metastatic cancers. One end of the receptor is attached to the ecm and the other end is attached to the cytoskeleton: knockout fak (focal adhesion kinase) in fibroblasts(cid:830)lack motility. If you k(cid:374)ock it out, it (cid:449)o(cid:374)"t (cid:373)o(cid:448)e: foci-clustering of integrin receptors, really do organize cytoskeleton, essential for the propagation of the tumor, b1 integrin + Induce cancer, you can introduce oncogene that causes transformation. Increase hyperplastic tumor nodules: b1 integrin . In b1 integrin (cid:829) cells with oncogene, nodules fail to form: possible way to interfere with development of certain tumors.
