PSYC3338 Lecture Notes - Lecture 19: Anterograde Amnesia, Synaptic Plasticity, Memory Consolidation
Document Summary
Fear, stress, and memory contribute to the neurobiology of ptsd. Ptsd patients are stuck in a full blown stress response involving all 3 (fear, stress, and memory) with each episode. Involved in encoding memory in the cortex. High cortisol levels impact hippocampus make it smaller. Clear memory of traumatic event, but faded memories of events that happened since that time . Fear conditioning, synaptic plasticity and the amygdala: implications for ptsd. Kerry ressler wrote a review paper on ptsd. Talks about the neural circuitry for learned fear (amygdala circuit -- paired stimuli like auditory tone and foot shock for rats) and molecular mechanisms known (basal lateral nucleus and central nucleus) Molecular stuff may show up on next exam as a bonus question!! Diagram in paper about development of ptsd and exposure that results in resilience/recovery . Two columns, two people very different. Memory consolidation is taking a short-term memory and turning it into long- term.
