BIOL-242 Lecture Notes - Lecture 26: Immunoglobulin M, Immunoglobulin D, Antibody

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Capable of binding specifically with antigen detected by b cells grouped into one of five ig classes. T- or y-shaped antibody monomer of four looping polypeptide chains linked by disulfide bonds. Two identical heavy (h) chains with hinge region at "middles" Variable (v) regions at one end of each arm combine to form two identical antigen-binding sites. Constant (c) regions of stem determine antibody class (igm, iga, igd, igg, or. Ige) serve common functions in all antibodies by dictating. Cells and chemicals that antibody can bind. How antibody class functions to eliminate antigens. Pentamer (larger than others); first antibody released. Potent agglutinating agent readily fixes and activates complement. Monomer or dimer; in mucus and other secretions. Monomer attached to surface of b cells . Monomer active in some allergies and parasitic infections. Causes mast cells and basophils to release histamine. B cells and switch antibody classes but retain antigen specificity. Antibodies inactivate and tag antigens; do not destroy them.

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