BIOL-242 Lecture Notes - Lecture 27: Severe Combined Immunodeficiency, Regulatory T Cell, Immunodeficiency
19 May 2020
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Document Summary
Douse recipient"s bone marrow with bone marrow from donor of new organ. "combined" immune system may treat transplanted organ as self. Harness regulatory t cell to suppress immune reactions. Congenital or acquired condition that impairs function or production of immune cells or molecules such as complement or antibodies. Severe combined immunodeficiency (scid) syndrome - genetic defect. Marked deficit in b and t cells. Fatal if untreated; treated with bone marrow transplants. Leads to immunodeficiency by depressing lymph node cells. Cripples immune system by interfering with activity of helper t cells. Characterized by severe weight loss, night sweats, and swollen lymph nodes. Caused by human immunodeficiency virus (hiv) transmitted via body fluids blood, semen, and vaginal secretions. Blood transfusions; blood-contaminated needles; sexual intercourse and oral sex; mother to fetus. Hiv multiplies in lymph nodes throughout asymptomatic period, ~10 years if untreated. Hiv-coated glycoprotein complex attaches to cd4 receptor.
