BIO ENG 10 Lecture Notes - Lecture 6: Radioactive Tracer, Ultimate Tensile Strength, Biocompatibility
Document Summary
Cartilage tissue - very few cells, strong and durable. Compressive strength (collagen 70%-90%), tensile strength (proteoglycan 10%-30%), reversible deformation (elastin 0-2%) Tendons - connect muscle to bone, high tensile strength, reversible extensibility. Collagen 27%, pgs 0. 03%, elastin ~0%, mineral 70% Liver tissue - essentially a complex network of very thin (1-2 cells thick) pipes, 90% hepatocytes (one type of cell), highly vascularized (lots of blood vessels) Material properties of tissue are dependent on types and ratios of ecm present, but composition is not the whole story. Other things that matter: crosslinking (long chains of polymers attached), anisotropy (direction), glycosylation (adding sugars), multiple levels of structure. Minimal immune response, non-toxic, no deleterious local or systemic effects. Pill dissolves -> drug passes into bloodstream -> drug is circulated -> drug diffuses through skin -> drug acts on bacteria. All these things happen simultaneously but at different rates. Divide a complicated system into a number of separate, typically well-mixed compartments.
