INTEGBI 114 Lecture 8: Lecture8
Document Summary
Lecture #8: terms, basic reproductive number, r0, expected number of cases caused by a typical infectious individual in a susceptible population. Individual reproductive number, v: expected number of cases caused by a particular infectious individual in a susceptible population, v varies among individuals, with population mean r0, z = actual number of cases caused by a particular infectious individual. Conventional model 1: completely homogenous population, everyone has same v = r0. Epidemic growth rates: heterogeneity major outbreaks are rare but explosive. Heterogeneity including superspreading is critical to the spread of many infectious disease. What does this mean for disease control: measures targeting more infectious cases are always more effective for a given control effort. Ix. population wide control vs individual specific control: reproductive number after control, population wide control, reduce v by a fraction c for all individuals, rc = (1-c)r0, reduces individual variation.
