MCELLBI 100B Lecture Notes - Lecture 28: Anaerobic Glycolysis, Warburg Effect, Oxidative Phosphorylation
3 May 2020
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Document Summary
Fast growing cells are sensitive to dna synthesis perturbation: a variety of drugs affect this pathway, stopping dna synthesis, used in therapeutic uses. Inhibit microbiome or other cells involved, some have anti-inflammatory properties. Coordination is done via hormones: cell surface receptor, peptide or amine hormone binds to receptor on the outside of the cell; acts through receptor without entering the cell. Insulin, glucagon, epinephrine: nuclear receptor, steroid or thyroid hormone enters the cell; hormone receptor complex acts in the nucleus, testosterone, retinoic acid. Interesting in the case of high amounts of energy/carbohydrates. The cell is promoting the usage of all this input resources. Multicellular organisms coordinate growth: growth factor: activation needed for nutrient uptake and utilization, mitogen: activation needed to drive the cell cycle. Induce angiogenesis: often hypoxic, selected to exist in unfavorable conditions. Microbes and proliferating human cells have similar metabolic goals.
