MCELLBI C44 Lecture Notes - Lecture 8: Semiconservative Replication, Dna Replication, Isocitric Acid
12 Feb 2017
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When both are heritable, that is epigenetics. Identical twins are essentially clones, but there are still differences! Twins are the best way to study diseases (one control and one diseased) Only 25% of identical twin pairs die of the same inherited diseases. If you have a genotype, following the central dogma, there will as a result also be a phenotype. But a single genotype can sometimes produce two very different phenotypes even when the environment are the same. Epigenetics: inherited differences without a difference in underlying dna. First clue was in the study of chromosomes in the early 2000s. Differentiation of many cell types from the fertilised egg is an example of epigenetic inheritance! Stem cell can create lots of different kinds of cells! (b-cells, myogenesis, neural cells, etc. ) Cells removed from an adult remember what type of cell they are! Epigenetic inheritance requires molecular memory and a mechanism of inheritance. The genome is the same in *all* cells.
