MCELLBI C64 Lecture Notes - Lecture 4: Schaffer Collateral, Temporal Lobe, Henry Molaison
22 Dec 2016
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Patient hm - severe epilepsy, 20-25 seizures a week. Area of the brain that is over active, over activity spreads through the brain. But didn"t have medicine in his time so removed part of temporal lobe (that was overactive) including hippocampus. After that unable to make new memories, but still remembered everything that happened to him before the surgery. Schaffer collateral (axons of ca3 cells) to ca1 pyramidal neuron is a synapse that we know the most about in the brain. Synaptic plasticity: long term potentiation (ltp) in ca1. Nmda (permeable to sodium, potassium, and calcium; important for learning and memory) Release glutamate, binds to ampa receptors, channel opens, sodium comes in, cell depolarizes. Glutamate also binds to nmda receptors, but wont open just for glutamate, they have a magnesium (mg27) block - channel will try to open but a magnesium ion will block it.
