NUSCTX 160 Lecture Notes - Lecture 4: Reverse Cholesterol Transport, Low-Density Lipoprotein, Lipoprotein Lipase

• School: Berkeley
• Department: Nutritional Sciences And Toxicology
• Course: NUSCTX 160
• Professor: Ronald Krauss

Document Summary

Lipoprotein macromolecule consisting of an outer soluble lipid-protein shell (phospholipids + unesterified cholesterol + apolipoproteins) enclosing a droplet of insoluble lipids (primarily triglycerides + cholesterol esters) Chylomicrons these are the largest and least dense of the lipoproteins, with the highest triglyceride content (>90%). They consist of a protein component synthesized in the liver, which wraps around diet-derived cholesterol and fats. There the fat is digested, while the cholesterol remains. It travels to the liver, where the cholesterol is metabolized. Thus chylomicrons deliver fats and cholesterol from the intestines to the muscles, fat cells and the liver. Vldl, very low density lipoprotein this is composed of protein, fats (60-70% tg), and cholesterol synthesized in the liver. It is converted to idl and ldl by removal of the apoproteins, except for one called apob-100, along with esterification of the cholesterol. (cid:862)takes o(cid:448)e(cid:396)(cid:863) i(cid:374) the fasting state. Idl intermediate density lipoprotein, is created by the metabolism of vldl.