PB HLTH 162A Lecture Notes - Lecture 14: Aedes Aegypti, Indoor Residual Spraying, Wolbachia
30 Dec 2019
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Document Summary
Dengue: flaviviridae (family), 4 serotypes, aedes aegypti & albopictus (mosquito vectors) Breakbone fever: getting infected with 1 serotype leads to more severe infection if patient gets infected a second time w/another serotype ( evidence for antibody-dependent enhancement) Tried pesticides/sprays, bed nets, protective measures & long-sleeved clothing. Zika: flaviviridae (family), aedes aegypti (mosquito vector), also transmitted vertically & sexually. Associated with congenital birth defects (ie- microcephaly) life cycle in birds & mosquitoes, humans & horses are incidental hosts. West nile virus: also associated with congenital birth defects (ie- viral encephalitis), Many asymptomatic infections: related to contaminated blood donor supply (now: screening of all donors) Lyme disease: borrelia, transmitted by ticks, treated by antibiotics but only in early infection (but often asymptomatic/minimal symptoms in early stages of disease) Malaria : transmitted by anopheles mosquitoes, treatment: artemisinin combination therapy, prevention: insecticide-treated bednets, indoor residual spraying, drain standing water. Plasmodium falciparum (more virulent strain of parasite) Antigenic variation allows it to avoid immune system.
