CAS BI 385 Lecture Notes - Lecture 23: Immunity (Medical), Yellow Fever, Toxoid
30 Mar 2018
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Document Summary
Bacillus calmette-guerin (bcg) (bovine tuberculosis: rotavirus, how rotavirus works: Each year: 2 million hospital visits, 600,000 deaths. Vp4 and vp7: major targets for neutralizing abs. Two sources of variability caused vaccine to take 30 years. (2) genome segments undergo re-assortment (11 linear dsrna segments: rotavirus vaccines. Attenuated human virus with common vp4 and vp7 variants. Mixture of 5 non-pathogenic rotaviruses from cattle. Disease leads to poliomyelitis (aka infantile paralysis) kills or cripples affected people (mostly children) public swimming pools. A major epidemic in 20 th century: various outbreaks associated with. Major public effort to develop a vaccine, successful campaign: subunit vaccines, instead of whole microbe, use antigens that best stimulate immune response, production, grow microbes in lab, break it apart and purify useful parts. Hepatitis b (against hb surface antigen, hbsag ) Problem: polysaccharide vaccine did not stimulate a cd4 t fh response (no peptide source), children under 18 months don"t make.
