CAS BI 315 Lecture Notes - Lecture 23: Proximal Tubule, Distal Convoluted Tubule, Electrochemical Gradient
15 Jan 2017
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Aldosterone makes this works (steroid hormone made in adrenal cortex) and acts on the cells of the distal tubule cortical collecting duct to make all the channels and pumps become expressed. Fine tuning hormone for na+ and k+ and also water: figure 14. 5 o macula densa part of the distal tubule right next to the arterioles; look like secretory cells. Cells in the macula densa are sodium sensors integrate the amount of sodium in the filtrate passing through the distal tubule at a certain time. Juxtaglomerular cells (jg cells) portion muscle cells on the afferent arteriole right next to the macula densa. When jg cells get stimulated, they release renin (enzyme) directly into the blood, which eventually activates aldosterone. In the blood renin acts on circulating protein that is always in your blood called angiotensinogen (made in the liver) angiotensinogen is an inactive precursor for angiotensin.
