CAS BI 315 Lecture 10: Lecture 10: The Endocrine System (continued)

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19 Aug 2016

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Hormones from each side of the pituitary influence levels in the other. The anterior pituitary is connected to the posterior (non-true) pituitary by blood supply. 2 polypeptide hormones (posterior pituitary gland: vasopressin/adh hormone discovered 2 separate times. Vasopressin raises bp and is stimulated by low bp often from injury. Adh decreases urine production by reducing the water excreted so that it returns to the blood. It is stimulated by low bp or low blood volume. However, if you eat salt all the time you will get chronic high blood pressure: salt-sensitive hypertensives are vulnerable to this, oxytocin is present in males and females, but its 2 functions only occur in women. Anterior pituitary gland (all hypothalamic and ap hormones are polypeptide hormones except da: each hormone has its own hypothalamic hormone (or 2), also called releasing hormone. There is no prolactin accelerator, only a break, which is dopamine. Prolactin is turned off at the end of pregnancy.

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3. The second stage of urine formation is called _________. Cells lining the proximal convoluted tubules (PCTs) have special projections called _________ which increase their surface area, thus enabling the PCTs to transport about 70% of filtrate back into blood. 4. When a person is dehydrated, their blood volume and blood pressure are too low. Two hormones reduce the loss of sodium and water from the body during dehydration by concentrating urine to prevent further water loss. The first hormone is secreted by the adrenal cortex and is called __________; this hormone stimulates sodium retention by nephrons. The second hormone is released by the posterior pituitary gland and is called _________; this hormone cause water retention by nephrons. 5. ___________is the waste product of cellular respiration (ATP synthesis). This waste product must be eliminated from the body because it becomes toxic at high levels. This waste product combines with water in blood to form carbonic acid, which is then converted into bicarbonate ions (HCO3-) and hydrogen ions (H+). Hydrogen ions lower blood pH, causing it to become too acidic. Kidneys are able to sense high H+ levels in blood and actively transport hydrogen ions (and other toxic blood borne chemicals) from blood into urine during ___________, the third stage of urine formation.

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. The kidneys contain millions of _________, which are the smallest functional units of the kidneys since each one can make urine from blood.

2. There are 3 stages in urine formation. The first stage is called____________; during this stage, blood pressure pushes water and small solutes out of a ball of capillaries called the __________ into the first part of the renal tubule called the _________ _________.

3. The second stage of urine formation is called _________. Cells lining the proximal convoluted tubules (PCTs) have special projections called _________ which increase their surface area, thus enabling the PCTs to transport about 70% of filtrate back into blood.

4. When a person is dehydrated, their blood volume and blood pressure are too low. Two hormones reduce the loss of sodium and water from the body during dehydration by concentrating urine to prevent further water loss. The first hormone is secreted by the adrenal cortex and is called __________; this hormone stimulates sodium retention by nephrons. The second hormone is released by the posterior pituitary gland and is called _________; this hormone cause water retention by nephrons.

5. ___________is the waste product of cellular respiration (ATP synthesis). This waste product must be eliminated from the body because it becomes toxic at high levels. This waste product combines with water in blood to form carbonic acid, which is then converted into bicarbonate ions (HCO3-) and hydrogen ions (H+). Hydrogen ions lower blood pH, causing it to become too acidic. Kidneys are able to sense high H+ levels in blood and actively transport hydrogen ions (and other toxic blood borne chemicals) from blood into urine during ___________, the third stage of urine formation.

6. Urine and blood differ in composition. In a healthy person, blood contains _________ , __________, and _________ but urine DOES NOT these materials.

7. Urine moves from the kidneys down the ureters into the bladder due to __________, a form of motility wherein _________ muscle tissue in the ureteral walls undergoes rhythmic waves of contractions.

8. The kidneys are located in the ___________ cavity; ureters conduct urine to the urinary bladder which is located in the pelvic cavity behind the symphysis joint of the _________ bones.

9. The three major systems which participate in the excretion of cellular wastes from blood include: the __________ system which eliminates urea and excess electrolytes like sodium; the ___________ system which eliminates water and salt; and the ____________ system, which eliminates carbon dioxide.

10. When the bladder is full, the _____________ reflex is initiated. During this reflex, the bladder walls contract and the ________ ________ sphincter, a circular structure made of _______ ______tissue, relaxes. Upon sensing an urge to urinate, a person can consciously contract their _______ _______ sphincter, a circular structure made of ________ ________ tissue - this stops the flow of urine out of the bladder and into the urethra until the time is convenient to urinate.

REFERENCE CITATIONS: _______________________________

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Key: A.Increase

B.Decrease

C. Remain thesame

For questions 19-20 use the following information Thyroid-stimulating hormone (TSH) is secreted from the anterior pituitarygland and acts on the thyroid gland to increase the secretion ofthyroid hormones. Thyroid hormones, on the other hand, have anegative-feedback effect on TSH secretion (See Fig. 16.8 in yourtext). For a person having normal thyroid function, the rate atwhich TSH and thyroid hormones are secreted remains within a normalrange of concentrations. In some people, however, the immune systembegins to produce an abnormal substance that functions likeTSH.

Predict what that substance will do to:

19. _____the rate of thyroid stimulating hormone secretion

20. _____ the rate of thyroid hormone secretion.

For question 21 use the following information. Background:Hormones are dissolved in blood plasma and transported either in afree form or bound to plasma proteins. Hormones that are lipidsoluble, such as steroids and thyroid hormone, circulate in theblood in combination with these plasma proteins. Hormones that bindto plasma proteins do so in a reversible fashion according to theequation:

H + BP <-----------> HBP

(Hormone) (BindingProtein) (Hormone bound to binding protein)

An equilibrium is established between the free plasma proteinsand the hormones bound to the plasma proteins. This equilibrium isimportant because only a free hormone is able to diffuse throughcapillary walls and bind to target cells. The combination of ahormone bound to a binding protein reduces the rate at which theydiffuse through the walls of capillaries.

This increases the half-life of the hormone. The half-life isthe length of time it takes to eliminate half a dose of a substancefrom the circulatory system. The half-life of a hormone is astandard measurement used by endocrinologists because it allowsthem to predict the rate at which a given hormone will beeliminated from the body.

21. _____How is the half-life of a hormone affected by adecrease in the concentration of the

specific plasma protein to whichthat hormone binds? Remember if the time to

eliminate a hormone from theblood stream is longer then the half life has increased.

If the time to eliminate ahormone shortens then the half life has decreased

22. _____Consider a hormone that is secreted in large amounts ata given interval, modified

chemically by the liver, andexcreted by the kidney at a rapid rate, making the

half-life of the hormone in thecirculatory system very short. The hormone therefore

rapidly increases in the bloodand then decreases rapidly. Predict the

consequences of liver and kidneydisease on the blood levels of that hormone.

For question 23 use the following background information:Periodic increases in the sensitivity of some tissues to certainhormones is called up-regulation. It results from an increase inthe rate of receptor molecule synthesis. In many tissues the numberof hormone receptors rapidly decreases after exposure to certainhormones. This is called down-regulation.

Problem. Estrogen is a hormone secreted by theovary. It is secreted in greater amounts after menstruation and afew days before ovulation. Among its many effects is causing

up-regulation of receptors in the uterus for another hormonesecreted by the ovary called progesterone. Progesterone is secretedafter ovulation. A major effect of progesterone is to cause theuterus to become ready for the embryo to attach to its wallfollowing ovulation. Pregnancy cannot occur unless the embryoattaches to the wall of the uterus.

23. ______Predict the consequences on becoming pregnant if theovary secretes too little

estrogen?

24. ______ Predict the effect of inadequate dietary intake ofcalcium on PTH secretion

25. ______ Predict the effect of inadequate dietary intake ofcalcium on Calcitriol secretion

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CAS BI 315 Lecture 10: Lecture 10: The Endocrine System (continued)

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