CAS BI 385 Lecture Notes - Lecture 6: Classical Complement Pathway, Innate Immune System, Superoxide Dismutase

• School: Boston University
• Department: Biology
• Course: CAS BI 385
• Professor: Trevor Siggers

Document Summary

Lecture 6: neutrophils: pathogen killing, neutrophil phagocytosis, granule and lysosome fusion in neutrophil phagocytosis, neutrophil takes in bacteria. nadph oxidase components enables respiratory burst: respiratory burst: transient increase in oxygen consumption by nadph oxidase (lead to superoxide, hydrogen peroxide) process, respiratory uses up o ( count the oxygens along the process) Critical function use h+, increases ph ( count the h+ along the. ): induced complement: mannose-binding lectin (mbl, binds to mannose-containing carbohydrates of pathogens, contains two proteases: masp1 and masp , mbl binding to pathogen, triggers lectin pathway of complement. Protein kinase r (pkr) inhibits protein synthesis and virion production: increase expression of ligands for receptors on nk cells, nk cells are lymphocytes of innate immunity. nk cells secrete cytokines and kill virus-infected. cancer/malignancy: nk cells interpret balance between activating and inhibitory signals, nk-cell synapse, localized area of cell-cell adhesion and communication. High concentration of activating and inhibitory receptor interactions.