CAS BI 525 Lecture Notes - Lecture 6: Synuclein, Quinone, Caspase 3
26 Sep 2016
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Class notes for bi525/ne525: lecture 7: alpha synuclein and. Parkinson"s disease (part 3: alpha-syn, formation of protofibrils a. i. Step 1: oxidation of dopamine and interactions with alpha-syn or with cys residues on different substrates a. i. 1. Dopamine quinone: pathological function in all pd b. i. All alpha-syn inherited mutations lead to dominant forms of pd associated with formation of aggregates b. ii. Wt alpha-syn binds to da quinone and forms protofibrils only in sporadic pd b. iii. Does this mean alpha-syn aggregation is playing a role in toxicitiy? b. iii. 1. Because of loss of physiological function alpha-syn does not bind to membranes, no control on da release b. iii. 2. Because of gain of toxic function formation of aggregates fibrils or oligomers c. Is it a gain of toxic function? c. i. Is the aggregate toxic itself- if so, large or oligomeric: model of fibrillization: ring-like structure (oligomeric structure) deposits on membrane which could break membrane d. i.
