CAS CH 273 Lecture Notes - Lecture 16: Citric Acid Cycle, Acetyl-Coa, Prochirality
16 Dec 2015
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Document Summary
Reaction #6: succinate dehydrogenase: all enzymes is second half are reversible (near equilibrium, note: fad used to make c=c, fadh2 is regenerated on the enzyme by ubiquinone (q) which is then reduced to, so to regenerate the dehydrogenase fadh2 fad and q qh2, q is a lipid soluble electron carrier (in membrane) ubiquinol (qh2): Regulation of cac: regulation at 3 irreversible steps: #1, #3, and #4, feedback inhibition from succinyl coa to citrate synthetase, product inhibition from citrate to citrate synthetase, activation by ca2+ ions (presence is usually a cellular signal for energy need, also adp. Citrate transport system: acetyl coa cannot cross the mito membrane this system allows c atoms from the mitochondria ac coa to be transferred to the cytosol, citrate and pyruvate can be transported in and out of mitochondria, allows lipid biosythesis in the cytoplasm, however, loss of energy gained by citrate synthase.
