CAS NE 525 Lecture Notes - Lecture 14: Apoptosis, Antigen, T Helper Cell
10 Aug 2018
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Document Summary
Lesions scarring tissue caused by released myelin from neurons cause edema which will help. That is where most of the damage is done. Less new forming lesions as disease progresses but neurodegeneration keeps progressing. Two goals in therapy depending on different phase we want to target. 1st phase: relapsing remitting - still has ability to cause formation of many new lesions want to prevent lesion formation with anti-inflammatory blocking inflammation response. Three drugs that target inflammation from three different pathways, used in combination. 2nd phase: degenerative progressive -sustained demyelination resulting in axonal loss, oligodendrocyte death (cells that produce myelin). Number of lesions that can be newly formed, wouldn"t targer inflammation target directly myelin, re- First line therapies: anti-inflammatorie - ifnb, glatiramer acetate, monoclonal antibody. Tysabri controls invasion of activated t cells. Control regulation of gene expression of genes involved in propagation of inflammation response (cytokines and chemokines). Goal is to regulate interferon stimulate gene expression.
