CAS PS 211 Lecture Notes - Lecture 7: Chemokine, Cytotoxicity, Apoptosis
15 Sep 2016
School
Department
Course
Professor
Document Summary
B cells and humoral immunity: humoral carried by antibodies (prod by lymphocytes)activate b cells , process that leads to production of antibody starts when. B cells exposed to free/ extracellular antigen- b cell activated, divides, differentiates into clone of many effector cells- plasma cells, plasma cells then produce antibodies directed against antigen that activated b cell, B cell from stem cells in red bone marrow in adults, liver in fetuses, after maturation, mature b cells mirgrate to lymphoid organs ( lymph nodes, spleen), once in organs, b cells recognize by antigen receptors. Apoptosis- rids body of unneeded cells, ex: elimination of activated macrophages terminate immune response. Activation of antibody producing by clonal selection : antibodies in b cell surface will bind only to one specific antigen, when approp antigen bings to antigen receptors on. B cell, b cell proliferates into clones- clonal selection, antigen selects lymphocytes that will multiply to form clone with same immunological specificity.
