BIOS 20175 Lecture Notes - Lecture 5: Transposable Element, Inverted Repeat, Chromosome
25 Jul 2020
School
Department
Course
Professor
Document Summary
Insertions -- one or more extra nucleotides that causes a frameshift. Deletions -- one or more nucleotides deleted that causes a frameshift and can alter the entire protein creates. Inversions -- when a segment of chromosome is reversed and then reattached in the same position. Amplifications -- segment of a chromosome is duplicated. Translocation and rearrangements -- recombination between homologous chromosomes. Loss of heterozygosity -- deletion removes the normal gene, and the other gene is mutated. This particular gene, due to the loss of one copy is known to be hemizygous. One strand vs. double stranded break (dsb) One strand breaks are easier to repair because the dna is still held together, while dsbs are more difficult. Transposon -- mobile genetic elements in their genomes. Is element: composed of a transposase gene and flanked inverted repeat sequences. Transposons have a gene that encodes for a transposase , which catalyzes mobilization of the transposon.
