AVS-3700 Lecture Notes - Lecture 20: Bioaccumulation, Vasoconstriction, Locoweed
1 Dec 2016
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Document Summary
Toxicology is primarily concerned with poisons and toxicants: occurrence. How are they produced: detection (methods for detecting, regulation. Action limits for protection from aflatoxins: properties. Can it be degraded by heat: effects where the rubber meets the road. Aflatoxin: produced by aspergillus fungi, one of the most powerful carcinogens in the world. When we exceed a threshold dose, we exceed the ability of the body to protect the animal. What is the defining characteristic of a toxicant: dose. Water toxicity syndrome: hyponatremia (decreased sodium concentration in the blood, water follows sodium -> the sodium inside the cells increases. This causes a problem in the brain and symptoms mimic those of brain injury. The dose response concept is the central concept in toxicology: there are two types of dose responses: It can be an infinite number of levels. Things like body temperature, hormone levels, and growth rate. Characterized by dose related changes in the severity of the toxic response.
