NUTR-4550 Lecture Notes - Lecture 1: Glutamine, Methionine, Oxaloacetic Acid

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27 Jan 2018
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Slide 1: using energy in response to a meal (figure 12. 7) Fatty acids will go through the carnitine-palmitoyl pathway and then b-oxidation to break down into acetyl-coa: this acetyl-coa will then enter the tca cycle and go through the electron transport chain to form atp. Glucose will go through glycolysis to release 2 pyruvate, go through the tca cycle, and then the electron transport chain. Amino acids have three routes after being ingested: 1. It can go straight into the tca cycle and then the electron transport chain (etc) The electron transport chain produce around 30 atp and water as a by product. Nadh and fadh2 have two different attachment points during etc: 2. An amino acid could become acetyl-coa to form ketone bodies (acetoacetate and beta-hydroxybutyrate) When in excess, the acetyl-coa could form fatty acids and be stored: 3. The amino acid could turn into pyruvate to enter gluconeogenesis. Purely ketogenic pathway proteins: leucine, lysine.

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