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BMS 420 (37)
Lecture

# Activity of VSMC in atherosclerosis, Fick's Law, fluid movement, Starling Equation, capillary pressure, colloid osmotic pressure

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Department
Biomedical Science
Course
BMS 420
Professor
Charles Miller
Semester
Fall

Description
12 September List of major objectives by Friday Quiz on Monday 10 questions worth total of 10 points 90% or above - +6 80 – 89.5 - +4 Test on Friday 21 st 30 – 40 questions MC/short answer Not more than 3 short answer Activity of VSMC (in atherosclerosis) Migration Proliferation Become foam cells Only about 1% are affected by growth factors to do so Fick’s Law Flux: amount of solute moving across capillary wall/time Mass Flow (Q) = S x P x ([x] – [Xc ) if S = Surface area Px= D /x = permeability coefficient a = wall thickness; D = diffusion coefficient [X]c– concentration in capillary [X]if concentration in interstitial fluid Capillary can thicken with edema Fluid Movement Capillary → interstitial spaces → lymphatic system Filtration related to hydrostatic and osmotic pressure imbalances 2 – 4 L filtered per day by lymph 180,000 L movement per day Starling Equation JV= L [PP – C ) –if (π – πC)] if Where J V rate of fluid flow L P filtration coefficient P = pressure C = capillary if = interstitial fluid σ = reflection coefficient to proteins (σ = 1 (no passage)) Filtration = movement from capillary to tissue Absorption = movement from tissue to capillary LPand σ L and σ differ between tissues P L Ps index of ability to conduct water Discontinuous capillaries show highest L and Powest σ Continuous capillaries show lowest L and highest σ (brain is extreme example)
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