ACCT 210 Lecture Notes - Lecture 32: Stem-Loop, Mhc Class I, Chromatin

• School: College of The Sequoias
• Department: Accounting (ACCT)
• Course: ACCT 210
• Professor: mohamed

Document Summary

Found in blood, secondary lymphoid tissues found predominantly in epidermis and gdtcr (gamma delta?) Mhc restricted (what it identifies) epithelia of reproductive and intestinal track. The beta chain variable region contains hypervariable regions. The alpha-beta cell receptor must interact with both peptide and mhc. Hinge regions give flexibility, transmembrane domain holds it in the membrane. Tcr specific for peptide one, can reshape subtly to enable better contact with peptide two: tcr must make contact with both peptide and mhc molecule; hence said to be. Alpha-beta receptor locus: similar in layout to the b cell receptor, tcrb chain genes have v segments (v), d segments (d) and j segments (j) = Immunoglobulin heavy chain: tcra chain has v segments, j segments (no d segments) = immunoglobulin light chain, but unlike immunoglobulins, there is a limited number of c segments. This is because the t cell receptor solely acts as a receptor.