BIOL 031 Lecture Notes - Lecture 27: Endoplasmic Reticulum, Reticulocyte, Myeloid Tissue
18 Sep 2020
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Wbc, etc. ) the mitotic precursor to blood cells before differentiation. Stem cell- 2 criteria, not in its spinal form, can become multiple types. Differentiation- maturing cell becomes committed to being certain of cells, can change into cell types, renew population type blood cells: erythropoiesis- the maturation, development, and formation off rbcs (erythrocytes, pathway. Hemocytoblast proerythroblast early (basophilic =blue) Erythroblast (hemoglobin) normoblast nucleus ejected when enough hemoglobin) reticulocyte (retaining some endoplasmic reticulum) erythrocyte. Reticulocyte erythrocyte 2 days in blood. Erythrocyte lifespan (primarily destroyed by macrophages in the spleen aka reticule ennhro system) 100-120 days: regulation of erythropoiesis, hormonal controls- erythropoietin is the hormone that stimulates rbc production. Decreased oxygen level in blood causes kidneys to increase release of erythropoietin. ** this process is called negative feedback mechanism. **erythropoietin now genetically engineered and synthesized by amgen of thousand oaks. **testosterone can also mildly stimulate production of rbcs in humans. 65% of fe in body is in hemoglobin.
