BIOL 031 Lecture Notes - Lecture 21: Rash, Microalbuminuria, Azotemia
22 Dec 2020
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Integrate the urinary findings to clinical history to help generate or narrow a differential diagnosis (mks 1a, 1d, 3c) Elevated creatinine over a short period of time - serial urine tests. Prerenal, intrinsic, and postrenal causes (refer back to other lecture) Elevated creatinine for at least 3 months, which means abnormal kidney function over time. Associated with aki but you need multiple creatinine values to confirm. Doubling serum creatinine or halving creatinine clearance in 3 months or less. Pathology often reveals crescentic gn where mononuclear cells infiltrate the bowman"s capsule. Often accompanied by endocapillary proliferation, focal necrosis, and tubulointerstitial cellular inflammation. > 3 g/day (wouldn"t this have to make it 4+?) Severe edema - patients with nephrotic syndrome look like crap - Hyperlipidemia - due to low protein levels in the blood, the liver makes a lot of fat (and there"s decreased lpl activity) Normal < 150 mg/day (most is tamm-horsfall, not albumin)
