BIO 303 Lecture Notes - Lecture 20: Frameshift Mutation, Start Codon, Rna-Dependent Rna Polymerase

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10 May 2019
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Deoxyribonucleotides make up dna and contain info to make proteins. One strand, template strand has mrna proteins. Triplet code aka 3 ribonucleotide letters make up one word . Unambiguous: each code can only code for 1 amino acid. Degenerate: 1 amino acid can be specified by multiple codes. Only tryptophan and methionine(aug) are encoded by a single codon. Orderly code: chemically similar amino acids share one or two middle bases in triplets encoding them. Universal: a single coding dictionary is used by viruses, prokaryotes, archaea, and eukaryotes. Mrna: transfers genetic info from dna proteins. The code that translates it to protein is in rna. Rna synthesizes triplet codes, joins short sequences (used in vitro) Frameshift mutation: insertions or deletions shift reading frame and change codons downstream. B/c of this mutation triplet code was discovered. Wobble hypothesis: initial two ribonucleotides of triplet codes often more critical than third(less constrained, not imp for base pairing rules)

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