MCDB 1150 Lecture Notes - Lecture 22: Beta Sheet, Glycosylphosphatidylinositol, Alpha Helix
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17 Nov 2016
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When channel is open, water soluble things can get in the membrane. B barrel antiparallel beta pleated sheet creates a large barrel. Places you will find this kind of configuration: Much be more than 2 amphipathic helices to form pore. Can be from a single helix coming together as a complex. Can be helices from a single polypeptide (polytopic) Clicker question the picture containing below shows a plasma membrane containing integral membrane proteins. B & c hollow cylinder looking structure is c. If you have a configuration like b squiggles going in and out of the membrane, you can"t tell if they"re amphipathic or not. The structure in a could form a channel if there were three of them coming together. The structure in b could form a channel if it were amphipathic. Clicker question you are trying to design a drug to block this pore. A hydrophilic molecule is soluble in water and could get into the channel.