BIOL 22000 Lecture 19: Lecture 19 Part 1
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2 Aug 2018
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Lecture 19
• Regulation of Secretion
o Movement of a substance from plasma into the nephron tubule after filtration has
taken place
o Mechanism for kidney to add to glomerulus filtration that kidney from to
eliminate
o Is always going to be against the concentration gradient
o This will always be active transport
▪ Active transport
▪ Secondary active transport
• Symporters and antiporters
o
o Proximal Tubule vs Distal Tubule
▪ Proximal tubule is set up to function for reabsorption, secretion, etc. in an
automatic way
• Regulated by the kidney, outside factor does not influence it
• Proximal tubule is always happening
▪ In distal tubule, reabsorption, secretion, etc. are often regulated by external
factors such as hormones
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• So, when kidney can vary what it’s reabsorbing or secreting, there
is an extrinsic regulation in distal tubule and collecting duct
o
o In the basolateral membrane, the potassium ATPase that maintain low
intracellular sodium concentration.
▪ The low concentration of sodium can be coupled with transporter in apical
membrane for transporting other ions
▪ One transporter the low intracellular sodium drive is the antiporter for
sodium going into the cell and H+ going out of the cell
▪ The secretion of H+ is a secondary active transport
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•
o The kidney does not generate water
o Kidney does not add water to the total volume, the best it can do is minimize
water lost
• Three Generalizations
o Na+ reabsorption is an active process
o H2O reabsorption is by osmosis (diffusion) and will follow Na+ reabsorption
(when possible)
o Na+ reabsorption and H2O reabsorption are independently regulated
• Active Reabsorption of Na+
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