HSCI 301 Lecture 1: Chapter 1 objectives(2)

• School: Drexel University
• Department: Health Sciences
• Course: HSCI 301
• Professor: William D' Andrea

Document Summary

Chapter 1: pharmacokinetics: understand what is meant by pharmacokinetics and how the 4 pharmacokinetic properties influence what the body does to the drug. Enteral: through the mouth (oral, buccal, sublingual) safe and convenient way of administration. Parenteral: through systemic circulation (iv, im, subcutaneous) useful for (cid:271)ioa(cid:448)aila(cid:271)ilit(cid:455) (cid:894)if there"s high first pass, the(cid:374) (cid:455)ou (cid:449)ould (cid:449)a(cid:374)t this to go past it through this shortcut) Iv = 100% bioavailability: understand the concept of oral bioavailability and area under the curve (auc) (calculation) , associate it to both oral and intravenous drug administration, and relate. Less bioavailability from oral administration than from parenteral like iv which gives you. 100% - when you ingest something orally, it will have to go through first pass hepatic system: things that are lipid soluble are more easy absorbed. 80% of blood circulation goes to the liver: understand the characteristics of a cell membrane, and the relationship of lipid and water.