BIO 263 Lecture Notes - Lecture 4: Tricalcium Phosphate, Bone, Calcium Hydroxide

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18 Jun 2018
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Course
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Bones
Skeleton- bones, cartilage, ligaments, connective tissues
- Bones are organs of skeletal system
- Would have fat short muscles without bones
Skeletal System Functions:
1. Support: for body, tissue, organs
2. Storage of minerals: calcium
3. Blood cell production: i.e. marrow
4. Protection: i.e. ribs protect heart and lungs
5. Leverage: can magnitude and direction
Axial- skull, vertebral column, ribs, sternum
Apendicular- limb bones
Osseous Tissue- bones
- Specialized cells and extracellular matrix
- ECM= ground fibers and proteins
- Matrix is solid due to calcium
Fibrous Periosteum- separates bones and other tissues
Cellular Endosteum- lines inner boney surface when osseous tissue when it surrounds other
tissues
Maxtrix
- Calcium phosphate Ca3(PO4)2 accounts for â…” of bone weight
- Interacts with calcium hydroxide to make hydroxyapatite:
- Inorganic insides of bone resist compression, can break when exposed to pressure,
twisting, bending, impacts (inflexible)
â…“ of weight is collagen fibers and noncollagenous proteins
Cells of Mature Bone
Osteocytes- mature bone cells, monitor protein and mineral content of matrix
- Directs calcium
- Lacunae- in layers of matrix where osteocytes are
- Lamellae- matrix layers
- Canaliculi- canals connecting lacunae looking for free surfaces and adjacent blood
vessels, diffuse nutrients
Osteoblasts- cuboidal, single layer on inner or outer part of bone
- Osteoid- organic components of matrix, responsible for osteogenesis
- Osteogenesis: producing new bones
- Respond to many stimuli
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Document Summary

Would have fat short muscles without bones. Skeletal system functions: support: for body, tissue, organs, storage of minerals: calcium, blood cell production: i. e. marrow, protection: i. e. ribs protect heart and lungs, leverage: can magnitude and direction. Cellular endosteum- lines inner boney surface when osseous tissue when it surrounds other tissues. Calcium phosphate ca3(po4)2 accounts for of bone weight. Inorganic insides of bone resist compression, can break when exposed to pressure, twisting, bending, impacts (inflexible) Of weight is collagen fibers and noncollagenous proteins. Osteocytes- mature bone cells, monitor protein and mineral content of matrix. Canaliculi- canals connecting lacunae looking for free surfaces and adjacent blood. Lacunae- in layers of matrix where osteocytes are. Osteoblasts- cuboidal, single layer on inner or outer part of bone. Osteoid- organic components of matrix, responsible for osteogenesis. Can produce daughter cells that differentiate into osteoblasts. Osteoclasts- multinucleated cells where bone is being removed. Same stem cells as neutrophils and monocytes.

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