ANT 333 Lecture Notes - Lecture 9: Thrifty Gene Hypothesis, Hyperglycemia, Liraglutide
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Document Summary
You would think that sumo wrestlers have insulin resistance (lol jokes they do) Discordance model (disease goes from rare to common) Main driver of serum cholesterol is dietary sugars and refined carbs. Turns into fatty acids in the blood, drives serum cholesterol up. High blood sugar causes nerve damage around the body, esp feet. The worse the nerve damage gets, the less you feel pain on your feet. If youre a kid you cant really control diet and exercise. Analog of glucagon lipeptide: hormone that affects gut, liver, pancreas. Kidney dialysis (kidneys have failed and they rely on machines to clean out their blood my. 95% see a resolution of type 2 diabetes. Most people diagnosed w diabetes, 55% have bmi of over 30. Gdm detected usually between 24&28 weeks gestation when insulin resistance. Makes it harder for baby to come out oh no. Glucose pours into the baby, baby gets fat.