NBB 301 Lecture 11: Lecture 11 Readings/Videos

• School: Emory University
• Department: Neuroscience & Behavioral Sci
• Course: NBB 301
• Professor: Frenzel Kristen

Document Summary

Www. mcb80x. org neuromodulators: neuromodulation overview, neuromodulation: synaptic transmission of info b/w 2 neurons can be made more/less efficient by third party. Other neurotransmitters/small molec released by third neuron making a synapse w/ either the pre-/postsynaptic neuron of interest: synaptic transmission: info typically exchanged unidirectionally from one neuron to another. -- chemical: mechanism: affect synaptic strength and communication b/w neurons, most g-protein coupled receptors (gpcrs): Structural: alteration in # (loss/addition) or size(growth/shrinkage) of synapses: development-- massive increase; shaped and re-shaped, end of life near normal aging -- diseases alzheimer"s /pd. Non-structural : changing synaptic strength --efficacy --- neuromodulation: processes of neuromodulation. Instead of 2 neurons in exchange, there are 3: nothing changes strxually of synaptic transmission but rather increase/decrease strength. Postsynaptically -- altering response to nt: nt can affect both ionotropic and metabotropic receptors, ionotropic receptors, can induce fast changes, ligand-gated ion channels (ligand=nt) Ion flow modulates membrane potential directly: metabotropic receptors, gpcr: very diverse; but similar strx.