NBB 402W Lecture Notes - Lecture 3: Patch Clamp, Neurostimulation, Microelectrode
19 Sep 2017
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Document Summary
The cuneiform nuclei are an adjacent region of the pedunculopontine nucleus and may play a major role in the initiation of gait. Cuneiform nuclei are involved in the generation of locomotion, and signals from the cuneiform nuclei activate central pattern generators in the spinal cord, mainly through the medullary reticulospinal tract. Ppn is located in the brainstem, caudal to the substantia nigra and adjacent to the superior cerebellar peduncle. Gabaergic: releases gaba; binding results in inhibitory function. Glutamatergic: releases glutamate; binding results in excitatory function: paragraph 2. The mlr is a functionally defined area of the brainstem that is associated with the initiation and control of locomotor movements in vertebrate species. Disordered physiological processes associated with a disease or injury. Chemical modulation and lesioning of cholinergic ppn impairs gait in monkeys. Mesencephalic locomotor region is modulated by changes in imagined locomotion in healthy humans.
