PSYC 210 Lecture Notes - Lecture 15: Pharmacotherapy, Schizophrenia, Antipsychotic
30 Apr 2018
School
Department
Course
Professor
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Monkey sees a triangle and unexpectedly gets a squirt of juice in its mouth.
Monkey's dopamine neurons
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Document Summary
Monkey sees a triangle and unexpectedly gets a squirt of juice in its mouth. Exhibit a "phasic burst" of firing because, hey, free juice. Do nothing because they don"t care about juice. Show a brief dip in firing because the juice wasn"t enough. The aberrant salience model of dopamine dysfunction in schizophrenia suggests that: Positive symptoms result from inappropriate firing of dopamine neurons to irrelevant or neutral stimuli. As if something was a reward predicting cue when it"s not. Positive symptoms result from excessive da release in response to actual reward-predicting cues. Schizophrenia is not a disorder of dopamine, but it"s likely involved in addition to many other biological factors. Can produce side effects similar to those of neurological disease why it"s also called neuroleptics. Atypical because at the time of creation, the typical one was first- generation. Tend to be more typical now and more used in treatment. Used for a variety of different conditions beyond psychosis.
