PCB 4594 Lecture Notes - Lecture 8: Regional Differentiation, Sox3, Growth Factor
Animal Hemisphere
Heavily pigmented portion of egg.
Contains egg nucleus.
-Gives rise to ectoderm
--> Sox3 and Ectodermin
Vegetal Hemisphere
Gives rise to endoderm and mesoderm
--> Vg-1 growth factor and Veg-TF
Which hemisphere does fertilization occur in?
Animal hemisphere
Which axis does fertilization establish?
Dorsal/Ventral axis
Where does the dorsal midline form?
Directly across the point of sperm entry
Nieukwoop Center
Critical for Dorsal/Ventral polarity formation
-forms across site from sperm entry
-first signaling center to be set up
Activation of wnt pathway in Nieuwkoop center causes localized expression of which proteins in the
dorsal region?
B-catenin
Xwnt-11
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