BSC 1086C Lecture Notes - Lecture 14: Bile Acid, Trans Fat, Glycogen Storage Disease
Document Summary
Catabolism of fat, glycogen, and proteins exceeds anabolism. Goal is to maintain blood glucose between meals: makes glucose available to the blood, promotes use of fats for energy (glucose sparing) In response to low plasma glucose, or during fight-or-flight or exercise, the sympathetic nervous system and epinephrine from the adrenal medulla promote: fat mobilization, glycogenosis. Hepatocytes: process nearly every class of nutrient, play a major role in regulating plasma cholesterol levels, store vitamins and minerals, metabolize alcohol, drugs, hormones, and bilirium. Structural basis of bile salts, steroid hormones, and vitamin d. Makes up part of the hedgehog singaling molecule that directs embryonic development. Transported in lipoprotein complexes containing triglycerides, phospholipids, cholesterol, and protein. Ldl (low-density lipoprotein)- cholesterol-rich; bad cholesterol : transport cholesterol to peripheral tissues for membranes, storage, or hormone synthesis, high levels of ldl, especially lipoprotein (a) increase the risk of heart attack. Vldls (very low density lipoproteins)- mostly triglycerides: transport triglycerides to peripheral tissues (mostly adipose)
