BSC 1010 Lecture Notes - Lecture 3: Protein Structure, Peptide, Covalent Bond

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20 Aug 2020
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LECTURE 3 Learning Objectives
Learning Objectives
Compare and contrast the different levels of protein structure and how they relate to
one another.
Explain the role of misfolded proteins in Alzheimer's Disease (AD) and prion diseases
Describe the structures and functions of nucleic acids, identifying key differences
between RNA and DNA.
Review Questions
1. What is the difference between a polypeptide and a protein? Given your answer,
would you say that the term "protein synthesis" when applied to the addition of
amino acids to a growing polypeptide chain is a misnomer? Why or why not?
2. What is the difference between a monomeric and a multimeric protein?
3. Describe the general structure and functions of biological molecules.
4. Describe the role of covalent & noncovalent bonds and interactions in determining
protein structure
5. Explain why the R group largely determines the properties of an amino acid and
how the properties of the R group determine where an amino acid will be located in
a protein or subcellular structure (we covered this last class as well).
6. Explain the basis of the primary and secondary structure of a protein.
7. What are the two types of secondary protein structure? Which types of bonds are
important in establishing these structures? Do these bonds involve the R groups of
the amino acid residues? Explain your answer.
a. Given your answer, is the R group of an amino acid irrelevant to the type of a
secondary structure a polypeptide can adopt? Why or why not?
8. Discuss the basis and significance of the tertiary structure of proteins, explaining the
differences between globular and fibrous proteins (which of these protein types are
characterized by the presence of extensive secondary structure?)
a. NOTE: Often, fibrous proteins are composed of a long polypeptide chain or an
association of long polypeptide chains that form a single repeating secondary
structure; nevertheless, we will encounter other types of fibrous proteins
later in the semester that have a markedly different structure.
9. Compare and contrast protein motifs, domains, and subunits discussing how each of
these relate to protein function.
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