BIOL 123 Lecture Notes - Lecture 10: Association Mapping, Quantitative Trait Locus, Heritability
Document Summary
Involves scanning through genomes of many different individuals, some with and others without, a focal trait of interest, to search for markers associated with expression of the trait. Requires detailed maps of the entire genome of a species, as well as genotype information for very large numbers of individuals. For this reason, they have proven most effective for humans and a few unusually well-studied genetic model species. Instead of crossing individuals from genetically divergent populations, gwa studies begin with large numbers of individuals sampled from within a single population. These individuals are grouped according to their phenotype - presence or absence of a particular disease, for example, Then they are compared, marker for marker, across the genome, in an attempt to identify alleles whose presence is correlated with the trait of interests. Refers to the pattern of phenotypic expression of a single genotype across a range of environments.
