BIOL 301 Lecture Notes - Lecture 11: Incubation Period, Envelope Glycoprotein Gp120, Dendritic Cell

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Immune system part 2: neutralizing antibodies do not work with hiv because of the variant mutants created in an individual. Those individuals that are capable of producing new neutralizing antibodies can delay the onset of aids: researchers at the university of texas believe they found a weak link in the gp120. Hiv is always replicating in the body; it never goes latent. When t-cells goes to fight hiv, hiv infects the t-cells and they are killed. The body then sends another set of t-cells to fight hiv, and they also become infected and die and the cycle repeats: two modes of infections occurring with hiv, active infection. Spread via hiv infected cells to other parts of the body including the brain. Through blood and by macrophages, dendritic cells, cd4+ t cells, free virus, etc. The pool of na ve t-cells becomes slowly drained: latent infection (in lymphoid tissues) Caused by infected t4 cells becoming memory cells (resting)

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