RIU 435 Lecture Notes - Lecture 18: Multicystic Dysplastic Kidney, Hydronephrosis, Renal Cortex

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Renal dysplasia occurs secondary to kidney obstruction in first or early trimester of pregnancy. Long- standing obstruction leads to development of fibrosis and cystic replacement of renal tissue. Incidence is 1 in 8000 births; only small number of obstructive kidneys progress to renal dysplasia. Unilateral caused by: ureteropelvic or ureterovesical junction obstruction. Bilateral obstruction dysplasia caused by: severe bladder outlet obstruction: urethral atresia or posterior urethral valves. Prognosis dependent on whether unilateral or bilateral. Bilateral involvement indicates poor outcomes due to renal. Unilateral involvement may vary from normal outcome to failure and lung hypoplasia dependence on associated anomalies or presence of anomalies affecting functioning kidney hydroureter (depending on level of obstruction) Early sonographic findings may only be hydronephrosis or. Early signs of dysplasia is presence of hydronephrosis with cortical cysts. Cortical cyst will not communicate with anechoic cystic- like appearance of hydronephrosis. As kidney slowly stops functioning, renal cortex becomes complete;ey dysplastic and replaced with multiple cortical cysts.

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