PSY 177 Lecture Notes - Lecture 18: Transcranial Magnetic Stimulation, Mood Disorder, Nmda Receptor Antagonist
31 May 2017
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Attempts to develop scz treatments without side effects led to atypical neuroleptics. Generally don"t have high affinity for da receptors. Can increase da release in frontal cortex. Excess da can"t be the whole explanation some people think it"s about dopamine imbalance = too much dopamine + too little activation in the frontal cortex. Phencyclidine (pcp, or angel dust) is a psychotomimetic, producing both positive and negative symptoms of schizophrenia. Pcp acts as a nmda receptor antagonist and prevents glutamate from acting normally. Glutamate hypothesis pcp is a glutamate antagonist (block receptors), and produces psychosis symptoms, maybe scz is also about reduced levels of glutamate. Unfortunately, nmda agonists produce seizures (creates excessive activity in the brain) and can be neurologically damaging. Integrative model: biological/brain predisposition + environmental stressors. Stresses of city life maybe, overstimulation, exposure to diseases (immune effect)i, stress of crowds, pollutants (again, not deterministic) Prenatal exposure to influenza that"s why there are so many campaigns for pregnancy health too.
