BIO 11 Lecture Notes - Lecture 22: Reuptake, Sinoatrial Node, Resting Potential

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On the surface of cardiac muscle are receptors for nor epinephrine. Nor epi binding leads to a removal of a phosphate group on gdp g protein activates. Takes atp and turn it into cyclic amp. Goes to sarcoplasmic reticulum; more calcium; increase concentration of calcium out of sr phosphorylates calcium channel; open channel, more calcium. Allows calcium to be re-consumed faster to allow faster contraction. Cardiovascular centers in brain - medulla cardio acceleratory side - sympathetic cardio inhibitory side - parasympathetic. Vagus nerve cranial nerve 10 - inhibitory in nature. When heart rate has to increase, cut connection with vagus nerve. Maintaining heart rate is a toggle between sympathetic and parasympathetic. In certain locations on the heart, they have different (more) excitability than the rest of the muscle; functions more like the nervous system. Unstable resting membrane potential - negative inside positive outside. Depolarization leads to action potential (charges change ) -70 to -90.

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