PSYC 1 Lecture Notes - Lecture 24: Bupropion, Paroxetine, Venlafaxine
Document Summary
Close relative of those who suffer from depressive or bipolar disorders are 10x more likely to develop a disorder of their own. The concordance rate for monozygotic twins is approximately 69% for bipolar disorder; whereas it is only 19% for dizygotic twins. The concordance rate for monozygotic twins is the same whether they are raised together or apart. A person"s first bout with depression is often observed after a period of extreme stress or trauma, and future depressive epsidodes can be retriggered by stressors. The diathesis stress model argues that depression arises due to. If the combination of the genetic predisposition and the stress exceeds a threshold, then the person will develop a depressive disorder. A negative correlation exists between lifetime depression and hippocampal volume. Depression has been loosely linked to the monoamine neurotransmitters. Reserpine, a drug used to treat high blood pressure, was reported in the 1950s to cause depression.
