BIOL-K - Biology BIOL-K 338 Lecture Notes - Lecture 2: Microorganism, Ptprc, Mast Cell
27 Jan 2017
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Monocytes (blood: converts to macrophage in tissue. Macrophage (tissues: can move through tissues (no specific name) or be in fixed tissues. Brain: microglial cells: long-lived (months-years, have granules in cytoplasm, can undergo respiratory burst, phagocytose foreign matter, apoptotic/necrotic cells, inorganic matter, antigen-presenting cells (acp) Material derived from phagocytosis loaded into class ii mhc [major histocompatibility complex] T-cells, b-cells, nk cells: (cid:862)all l(cid:455)(cid:373)pho(cid:272)(cid:455)tes are leuko(cid:272)(cid:455)tes, (cid:271)ut (cid:374)ot all leuko(cid:272)(cid:455)tes are l(cid:455)(cid:373)pho(cid:272)(cid:455)tes(cid:863) All t-cells are cd3: helper t-cells. Control all specific immune responses (adaptive immunity) Humoral (b-cell) or cell mediated immune responses require presence cd4+ cells. Hiv deletes cd4 from body (develop aids) Ca(cid:374)"t re(cid:272)og(cid:374)ize a(cid:374)tige(cid:374) i(cid:374) (cid:374)ati(cid:448)e state (cid:894)(cid:272)a(cid:374)"t (cid:271)u(cid:373)p i(cid:374)to it(cid:895) Mhc class ii (apc) presents fragments to t-helper cells: antigen presenting cells: macrophage/monocyte, dendritic cells, b-cells, cytotoxic t-cells. Mhc class i must present antigen fragments. Virtually all cells in body express i mhc (internal feedback loop) Helps to determine abnormal proteins in human cells.
