BUS 17 Lecture Notes - Lecture 13: Anti-Social Behaviour, Orbitofrontal Cortex, Disinhibition
Document Summary
From genes to brain to antisocial behavior summary (raine) A genes to brain to antisocial behavior" model hypothesizes that specific genes result in structural and functional brain alterations that, in turn, predispose to antisocial behavior. Key concept highlighted in review is specific genes result in structural and functional brain alterations that, in turn, predispose to antisocial behavior. Antisocial behavior viewed as dimension, and is defined as failure to conform to social norms for lawful behavior. Little scientific doubt that genes play significant role in antisocial behavior. Reviews of twin and adoption analyses provide evidence that about 50% of variance in antisocial behavior is attributable to genetic influences. Maoa gene implicated to play role in antisocial behavior. Gene being knocked out in mice = aggressive behavior; knocked back in = normal behavior. In humans environmental complexities requiring further clarification. Important to find out which of associated genes code for brain impairments found in antisocial groups.
