BIOS10115 Lecture Notes - Lecture 6: Antimicrobial Resistance, Intracellular Parasite, Veterinary Virology
3 Dec 2016
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No cell membrane, nucleus, organelles or cytoplasm. Obligate intracellular parasite: only replicate when within a living cell. Contain either dna or rna surrounded by protein (capsid) Viruses are too small to be seen with a light microscope (20 300 nm) Steps: adsorption, penetration, synthesis, maturation, release. Have been used to treat patients with antibiotic resistant infections: common treatment in russia. Advantages: cheap, few side effects (but needs more testing, phages are very specific. Lysogeny when a virus does not lyse the cell (virus becomes part of the host cell genome and is called prophage or a provirus). Endocytosis the virus enters within the cell. Depends on the type of virus: occurs either in nucleus or cytoplasm of host cell and uses host cell machinery. May or may not kill host cell. Lysis of cells causes clinical symptoms: destruction of skin cells herpes, pox, destruction of nerve cells polio.
