CHEM46497 Lecture Notes - Lecture 12: Chromophore, G1 Phase, Rhodopsin
12 May 2016
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Document Summary
Understand the mapk pathway and the common characteristics of these enzymes. Mitogen activated protein kinase a mitogen is a protein that triggers the cell to undergo mitosis. Activation is usually dependent on two phosphorylations and a three tiered pathway architecture anchored to ksr, a scaffolding protein. The substrate recognition sites for mapk pathways are similar. Explain how it is similar to the insulin receptor, but different in two ways. Erythropoietin receptor similar to insulin in that it is dimerized and needs to be phosphorylated to be activated. Epo however, has no inherent protein kinase activity, it requires jak to bind and phosphorylate it. Jak is similar to the beta domain of the insulin receptor: not involved in mapk, instead, initiates cascade to form stats. Shc bind sh2 sites which have a high affinity for phosphorylated tyrosines. What is a stat, explain how they are activated, dimerize, and enter the nucleus.
